A Functional Link Between SIRT1 Deacetylase and NBS1 in DNA Damage Response
نویسندگان
چکیده
منابع مشابه
Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum.
Ataxia-telangiectasia (A-T) and Nijmegen breakage syndrome (NBS) are related genomic instability syndromes characterized by neurological deficits. The NBS1 protein that is defective in NBS is a component of the Mre11/RAD50/NBS1 (MRN) complex, which plays a major role in the early phase of the complex cellular response to double strand breaks (DSBs) in the DNA. Among others, Mre11/RAD50/NBS1 is ...
متن کاملFunctional link between DNA damage responses and transcriptional regulation by ATM in response to a histone deacetylase inhibitor TSA.
PURPOSE Mutations in the ATM (ataxia-telangiectasia mutated) gene, which encodes a 370 kd protein with a kinase catalytic domain, predisposes people to cancers, and these mutations are also linked to ataxia-telangiectasia (A-T). The histone acetylaion/deacetylation- dependent chromatin remodeling can activate the ATM kinase-mediated DNA damage signal pathway (in an accompanying work, Lee, 2007)...
متن کاملDBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage.
Human DBC1 (deleted in breast cancer-1; KIAA1967) is a nuclear protein that, in response to DNA damage, competitively inhibits the NAD(+)-dependent deacetylase SIRT1, a regulator of p53 apoptotic functions in response to genotoxic stress. DBC1 depletion in human cells increases SIRT1 activity, resulting in the deacetylation of p53 and protection from apoptosis. However, the mechanisms regulatin...
متن کاملNBS1 and multiple regulations of DNA damage response
DNA damage response is finely tuned, with several pathways including those for DNA repair, chromatin remodeling and cell cycle checkpoint, although most studies to date have focused on single pathways. Genetic diseases characterized by genome instability have provided novel insights into the underlying mechanisms of DNA damage response. NBS1, a protein responsible for the radiation-sensitive au...
متن کاملFunctional Role of NBS1 in Radiation Damage Response and Translesion DNA Synthesis
Nijmegen breakage syndrome (NBS) is a recessive genetic disorder characterized by increased sensitivity to ionizing radiation (IR) and a high frequency of malignancies. NBS1, a product of the mutated gene in NBS, contains several protein interaction domains in the N-terminus and C-terminus. The C-terminus of NBS1 is essential for interactions with MRE11, a homologous recombination repair nuclea...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2007
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.6.23.5026